KMID : 0043320160390020154
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Archives of Pharmacal Research 2016 Volume.39 No. 2 p.154 ~ p.160
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Cytotoxic and anti-inflammatory activities of phenanthrenes from the medullae of Juncus effusus L.
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Ma Wei
Zhang Yue Ding Yun Yun Liu Feng Li Ning
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Abstract
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Bioactivity guided phytochemical investigation of the ethanol extract of the medullae of Juncus effusus resulted in the isolation of two new phenanthrenes, 8-hydroxymethyl-2-hydroxyl-1-methyl-5-vinyl-9,10-dihydrophenanthrene (1), and 5-(1-methoxyethyl)-1-methyl-phenanthren-2,7-diol (2) together with 15 known phenanthrenoids (3?17). The chemical structures of 1 and 2 were established by a combination of spectroscopic techniques. Compounds 1?15 and 17 were evaluated for their cytotoxic activities against five human cancer cell lines (SHSY-5Y, SMMC-7721, HepG-2, Hela and MCF-7) by CCK-8 assay, and their anti-inflammatory activities were also evaluated by inhibition on NO production in LPS-activated murine macrophage RAW 264.7 cells.
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KEYWORD
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Juncus effuses, Juncaceae, Phenanthrene, Cytotoxicity, Anti-inflammatory activity
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